February 27, 2017

Biobanks A-Z



Biobank NameDescription
ABC: The Adjuvant Breast Cancer International TrialThe ABC (CT) Trial is a pragmatic randomised phase III trial where patients diagnosed with early stage breast cancer were randomised to standard CT versus none against a background of prolonged (5 years) tamoxifen and with or without ovarian ablation or suppression. Trial endpoints included relapse-free survival (RFS) and overall survival (OS). Between 1993 and 2000, 1991 (987 CT, 1004 no CT) patients were randomised from 106 UK and 16 non-UK centres. 62% patients were age >50 years, 57% node p
Add-Aspirin Translational SamplesCollection of whole blood samples for plasma and DNA extraction and formulin-fixed paraffin-embedded (FFPE) tumour samples
Apheresis MNC CollectionA cell bank of allogeneic ?? T cells required to ensure that an adequate supply of ?? T cells is available for research and development purposes as well as to conduct future clinical trials using ?? T cells (unmodified or modified) as IMP.
A-PREDICTA-PREDICT is a single group, single agent, open label multicentre phase II study which aims to define the activity of the VEGFR inhibitor axitinib in patients with metastatic renal cell carcinoma of predominant clear cell histology where nephrectomy is not immediately indicated. 99 participants from up to 20 centres will receive daily axitinib until disease progression. Primary endpoint: The proportion of patients treated with axitinib who are free from disease progression 6 months from the
Archival gastro-intestinal tissue, blood, saliva and urine collectionTissue bank contains paraffin blocks, a limited number of frozen tissue samples, frozen buffy coat, plasma and serum, frozen urine and frozen saliva.
Arden Tissue BankArden Tissue Bank operates under a Human Tissue Authority post mortem licence within a district general hospital. The biobank has generic , ethical approval and is able to collect tissues prospectively across a wide range of tissue types. In addition the biobank has access to the full pathological archive across three hospital sites. The cellular pathology archive alone totals almost 2 million blocks, with full patient data available for the last 10 years.
ARISTOTLE TrialARISTOTLE is a multicentre, phase III, randomised trial comparing standard neoadjuvant chemoradiotherapy (CRT) of oral capecitabine and radiotherapy versus standard CRT with the addition of irinotecan. 600 patients with MRI defined locally advanced, non-metastatic rectal cancer will be allocated in a 1:1 ratio to the two treatment arms. Samples collected for translational research as part of the trial: (i) archival tumour tissue blocks (from diagnostic biopsy), (ii) tumour tissue blocks a
AstraZenecaAstraZeneca has a global biobank network storing human biological samples from AZ sponsored clinical trials, collaborations and also procured samples. These samples span the following main therapy areas: Oncology, Cardiovascular and Metabolic Diseases, Respiratory, Inflammation and AutoImmunity, Neuroscience. There are over 1 million samples logged in the AstraZeneca Biobank Application (ABBA). Work needs to be done to identify which specific sample sets can be shared (both from closed clinical
Avon Longitudinal Study of Parents and Children (ALSPAC)The Avon Longitudinal Study of Parents and Children (ALSPAC) is a longitudinal cohort study which has been charting the health of 14,500 families in the Bristol area since the early 1990s in order to improve the health of future generations. The study is also known as the Children of the 90s study. Mothers were recruited during pregnancy. The children born in 1991 and 1992 (known as ALSPAC-G1) and their mothers and fathers (G0) have been followed since. A large amount of phenotypic and enviro
Baby Bio BankThe Baby Bio Bank is a collection of over 50,000 biological samples and medical data collected fromover 2,500 pregnancies affected by recurrent miscarriage, preterm birth, intrauterine growth restriction and pre-eclampsia. We have also collected samples from pregnancies complicated with other medical conditions such as Diabetes, high BMI, hypertension, IVF, twin and a cohort of samples from uncomplicated pregnanciess. We hold DNA, RNA, serum, plasma and whole blood from both parents and urine f
Barts BioresourseThe purpose of the Bart?s Bioresource was to establish a repository of generic consented patients clinically managed by Cardiac Services at Bart?s Health NHS Trust. In addition to this the consent includes the donation of human blood, tissue donation (e.g. atrial appendage or pulmonary vein tissue) for the purpose of establishing a biobank of samples for use in cardiac disease research. The patients are informed that ?The purpose of the Bart?s Bioresource is to allow research into diseases of
Barts Cancer Institute Breast Tissue Bank This ground breaking initiative will see the Barts Cancer Institute and 4 other centres around the country working together as one national resource, to house the multi-million pound Breast Cancer Now Tissue Bank. Professor Louise Jones and a dedicated team head up the Tissue bank in the Barts Cancer Institute. The tissue bank includes a dedicated cell culture team, and has just established the Metastatic Bank including a Rapid Autopsy Programme. In the coming years we will see the benefits to
Barts CTUWe conduct research into the prevention of cancer with particular focus on preventive therapy and screening. We are involved in clinical trials and epidemiology.
Barts Gynae Tissue BankThe purpose of the Barts Gynae Tissue Bank is to collect, store and share high quality tissue for translational research into gynaecological cancers. We collect gynaecological tissues, ascites, blood and urine that have been obtained during standard diagnostic and therapeutic procedures and are surplus to pathological diagnostic requirements. Tissues are collected from both primary and metastatic gynaecological cancer as well as from non-malignant tissues obtained in the course of standard inve
Barts Pancreas Tissue BankPancreatic diseases can be very difficult to diagnose and monitor because of the location of the pancreas deep within the abdomen. Also, with the current range of tests it may not be possible (in some cases) to tell the difference between pancreatitis (inflammation of the pancreas) and other conditions such as cancer of the pancreas without surgery and direct biopsy of tissues from this organ. This project is aimed to create a research tissue bank (explained below), specifically for pancreatic d
BEST3 TrialThe BEST3 Trial is a Cluster Randomised Controlled Trial comparing the Cytosponge?-TFF3 test with usual care to facilitate the diagnosis of oesophageal pre-cancer in primary care. The following types of the samples are collected as part of the Trial methodology: ? Cytosponge? samples ? Saliva samples (TFF3-positive Cytosponge? cases) ? Endoscopic biopsy samples including gastric cardia and clinically-indicated oesophageal biopsies Cytosponge? and endoscopic biopsy samples will be further p
Biliary Tract Cancer Virtual Tissue BankWe plan to create a national virtual tissue bank of tissue samples from Biliary Tract Cancer patients who have participated in a clinical trial, and their associated prospectively collected clinical trial data, for high quality, peer reviewed and ethically approved research. Samples will be collected and stored in three separate Biobanks: 1) UCL/UCLH Biobank for Studying Health and Disease 2) Manchester Cancer Research Centre (MCRC) Biobank 3) Southampton Biobank Central Coordination of
Biobank for patients with retinal degenerations & dystrophiesOuter retinal disease is the most common cause of blindness in the UK. It can be caused by a variety of single gene defects, including conditions such as retinitis pigmentosa which often result in early onset blindness in childhood, whilst the risk of age related macular degeneration is caused by a variety of complex multigene defects causing visual loss in later life. Treatments are evolving for both diseases but the underlying pathogenesis and treatment of these diseases remains elusive. We
BioDockProud to be an industry leader in cryogenic storage. Our state-of-the-art facilities are based in the UK and Switzerland. Storing over 500,000 samples from over 70 different countries
Biology of the Human Uterus in Pregnancy and Disease Tissue BankThis tissue bank was established to support the research of members of the Centre for Trophoblast Research at the University of Cambridge into maternal-fetal interactions during pregnancy. Because of the limited number of samples available it is not possible to supply tissues to external researchers unless in the context of a collaborative project with a member of the Centre.
Bloodwise Childhood Leukaemia Cell BankThe Bloodwise Childhood Leukaemia Cell Bank is a national collection of samples from children and young people with paediatric haematological malignancies. It is very well annotated with demographic, clinical and genetic features. This annotation enables identification and curation of very rare subgroups. There is a range of sample types including viable cells and DNA from bone marrow, plasma and CSF supporting many different types of project. The Bank is open to international as well as UK-
BOXITA randomised phase III placebo-controlled trial evaluating the addition of celecoxib to standard treatment of transitional cell carcinoma of the bladder
Brain Images of Normal Subjects - Brains ImagebankThe BRAINS (Brain Images of Normal Subjects) Imagebank is a collection of anonymised MR images and associated clinical data. It includes ?normal? individuals at all ages (from prenatal to old age). The data were collected from individuals participating in healthy volunteer studies, or control groups
BRAIN UKBRAIN UK is a virtual brain bank which provides access to tissue already available in NHS archives as well as the provision of generic ethics. The BRAIN UK network includes 23 of 24 Neuropathology Centres across the UK.
BRASH Brain Tumour Bank South West, BristolThe aim of the brain tumour bank is to provide researchers with access to rare tumour tissue from the brain and spinal cord (which is surplus to diagnostic needs).The brain tumour bank has the approval of the National Research Ethics Service and is held under the Human Tissue Authority licence at North Bristol Trust. The bank is supported and regulated by Research and Innovation, North Bristol Trust.
Bristol BiobankThe Bristol Biobank (funded by the David Telling Charitable Trust with stakeholders from the University of Bristol and University Hospitals NHS Foundation Trust) stores samples collected from patients and healthy volunteers for use in biomedical research. Researchers in Bristol and beyond can apply to use these samples in their research. The collection of a wide range of samples will provide a platform for research into complex conditions. Researchers may request to deposit samples into the B
BTNW Archival CNS tissue, blood & CSF bankCollection covering both neuro-oncology and neuro-degenerative diseases. Comprises brain tumour samples of all types (PET, FF & cell culture) as well pre-/post-operative, neurological and control blood samples and CSF.
Cambridge Blood and Stem Cell BiobankCambridge Blood and Stem Cell Biobank collects and curates blood and blood-product derived samples from normal individuals and patients with blood and related malignancies, with particular emphasis on accessibility to purified tumour and stem cell populations from these samples. Set up in 2009, by 2016 the bank already contains over 12,000 samples, 70% from patients enrolled on research studies and clinical trials, and the remainder from cord blood donors. We specialise in bespoke fresh specimen
Cam-UroOnc BiorepositoryThe primary role of the CamUro-Onc is to consent, collect, log and store frozen tumour/normal tissues, blood and urine for use in approved research projects. The bank has been in operation since 2003 and now has an extensive collection of biosamples from urological diseases. Type of samples collected; - Fresh frozen and paraffin wax embedded tumour/normal tissue (where possible) from kidney, bladder and prostate. - Matching blood and urine samples. - Blood and urine samples collected as pa
Cancer Group CTR Cardiff trialsCentre for Trials Research Cardiff University. Trial sample collections
Cancer Tissue BankControlling metastasis is an essential requirement for cancer management. The current model systems pay scant attention to human biology due to scarcity of evaluable patient samples. We propose an expansion of the tissue banks at the Barts Cancer Institute to include the collection of metastasis from a variety of primary tumours as well as distinct metastatic sites for use in laboratory research. This will facilitate identification targets to control tumour spread and develop novel biomarkers.
Cardamon Clinical Trial SamplesSamples taken as part of the Cardamon clinical trial
Cardiff School of Dentistry Tooth BankCollection of both deciduous and permanent teeth. Collection of fresh teeth for extraction of pulpal cells can be arranged.
Cardiff University BiobankThe Cardiff University Biobank is a centralised biobanking facility sited at the University Hospital of Wales. We offer high quality human biosamples for research undertaken for patient and public benefit to academic and commercial organisations. We have established collections from a number of different disease areas and welcome approaches to initiate new collections not already established within the facility. The biobank also welcome applications to deposit samples from completed research p
CASPS: A Phase II trial of Cediranib in ASPS patientsCASPS is a two-arm, randomised, double-blind, placebo-controlled, Phase II trial of cediranib in ASPS patients. The primary objective is to evaluate the efficacy of cediranib by measuring the percentage change in the sum of target marker lesion diameters from randomisation to week 24 compared to placebo. Secondary objectives include: progression-free survival, overall survival and safety and tolerability of cediranib in ASPS patients. Tissue markers of tumour response, circulating markers of ang
CEPA Biobank NewcastleThe CEPA Biobank can provide samples to both Researchers and Commercial companies on a cost recovery basis. We mainly work on a prospective collection basis, providing samples to specified instructions.
CHHiPConventional or Hypofractionated High Dose intensity Modulated Radiotherapy for Prostate Cancer
Children's Cancer and Leukaemia Group (CCLG) Tissue BankNational collection of childhood, teenagers and young adults solid tumour samples and lymphomas in the UK. Samples are centrally stored at the Central Bank, Newcastle University.
CIGMR BiobankAn ISO9000 accredited biobank for the processing, storage and distribution of large cohorts.
CMFT BiobankOur biobank is a resource for health research available to all bona-fide researchers via our application process. We hold a large collection of human biological samples with associated clinical information. All human biological samples collected by The Biobank have full ethical approval, and is handled within the conditions of the ethical approval gained, in accordance with the requirements of the Human Tissue Act 2004 and under the governance of the Human Tissue Authority (HTA) Licence (#12
Daisy Tumour BankThe Daisy Tumour Bank (DTB) is creating various collections of human samples to share with researchers, thus providing a resource of fit for purpose biological material to facilitate ethically approved cancer research. The DTB is collecting human tissue and blood samples from cancer patients within Hull and East Yorkshire Hospitals NHS Trust. The DTB is a newly established biobank which is in the accrual process, therefore samples and data are not accessible to researchers at this time.
DARWIN1 TrialBlood and tissue from lung cancer patients
Deciphering Antitumour Response and Resistance With INtratumour Heterogeneity (DARWIN II)A phase II, multi-centre, non-randomised, molecularly stratified trial for NSCLC patients to study tumour heterogeneity using genomic analysis
DOC-MEKA double-blind randomized phase II trial of docetaxel with or without selumetinib (AZD6244; ARRY-142886) in wt BRAF advanced melanoma. The aim of this study was to assess the efficacy and safety of selumetinib combined with docetaxel as first-line treatment in patients with wild-type BRAF advanced melanoma.
Donate For Research Initiative (DRI)Focusing on the procurement and supply of Fresh Biological Human samples and prospective studies. Open collaborations with other research Tissue Banks to facilitate multidisciplinary research and coordinated collections to benefit life science researchers.
Early Pregnancy Tissue CollectionEmbryonic and fetal tissue (including placenta) collected from voluntary terminations of pregnancy
East London Genes & HealthEast London British-Bangladeshi and -Pakistani adults, age >=16. Population sample. Stage 1: target 100,000 oragene saliva (& extracted DNA) chip genotyping, exome/whole genome sequencing e-health records - primary care, secondary care, national NHS Digital datasets and Disease Registries consent for recall Stage 2: metabolic health assessment, target 14,000 biobanked blood (DNA, protein, RNA, plasma, serum) GE Lunar iDXA Echosens liver fibroscan bioimpedance optos digital retina
eLIXIR - Early Life Data Cross-Linkage in ResearchThe embryo, fetus and newborn child are very sensitive to external influences during development. These can arise from problems with the mother's health, her lifestyle, her physical environment, medication, the placenta not working properly, complications during birth, or as consequence of being born too early. Adversity in these periods of developmental vulnerability can have persistent effects on the long-term health of the child, including physical and mental health disorders. We also know th
EPHOS-B TrialEffect of Perioperative AntiHER-2 Therapy on Early Breast Cancer Study ? Biological Phase (EPHOS-B). The EPHOS-B trial is a multicentre, three group, randomised controlled trial conducted in two parts. Part 1 (protocol versions 1 to 4): HER2+ patients were allocated in a 1:2:2 ratio to control, perioperative trastuzumab only or perioperative lapatinib only. This part of the trial will be superseded by Part 2 following the approval of amendment 5 by West Midlands - Edgbaston NRES Committee
Epilepsy Society Brain and Tissue BankThe Epilepsy Society Brain and Tissue Bank is a recently established tissue bank at the Institute of Neurology, which has ethical approval and is supported by the Epilepsy Society. It is located within UCL Institute of Neurology in the Department of Neuropathology and is governed by a committee including members of the Department of Clinical and Experimental Epilepsy, the Epilepsy Society as well as SUDEP Action. The collection comprises consented tissue samples from patients who have undergone
ESPAC-TPlusTo centralise tissue and other clinical samples from the ESPAC studies, and make them available for future studies. Storage of the samples is designed to facilitate specific studies on response to chemotherapeutics. These separate studies will be subject to individual ethics applications. If successful they will allow subgroups of patients to be identified who will be predicted to benefit from particular chemotherapeutic regimens, improving survival for individual patients and facilitating clini
Ethical Tissue - University of BradfordEthical Tissue is a research tissue bank, licensed by the Human Tissue Authority (HTA); to collect, store and supply a wide range of human tissue, cells and fluids to biomedical research groups in academia and industry. Also includes tissue donated after death.
Extracted teeth BiobankSamples and data are donated on the basis that they will be used for the benefit of other patients and for society in general. The bank plans to maximise benefits to society by using the extracted teeth to develop improved methods of detecting tooth decay. The caries detection rate of different methods can then be compared with the "ground truth". which uses an histological examination of the teeth. We propose to publicise the existence of the bank on
Faculty of Medicine Tissue Bank (SHARe Project)We have trios of DNA samples from families of children showing symptoms of ADHD, Anxiety and Conduct Disorder.
Generation ScotlandA collaboration between the Universities of Edinburgh, Glasgow, Dundee and Aberdeen, and NHS Scotland, to provide resources for genetic and medical research.
GlaxoSmithKline Research Tissue Bank GlaxoSmithKline R&D has a global biobank network storing human biological samples from GSK R&D sponsored clinical trials, collaborations and commercially procured samples. These samples span the following main therapy areas: Oncology, Cardiovascular and Metabolic Diseases, Respiratory, Inflammation and AutoImmunity. There are several million samples logged in the GlaxoSmithKline R&D sample tracking systems. Work needs to be done to identify which specific sample sets can be shared (both from clo
GoDARTSThe GoDARTS Study has stored specimens of whole blood, serum, urine and DNA from consented patients with type 2 diabetes and matching controls (non diabetics) resident in the Tayside region of Scotland. Additionally GWAS data on ~10,000 cases is available. This resource is available to researchers worldwide to help define genetic factors related to diabetes including susceptibility, complications and response to treatment.
GoSHARE (Genetics of the Scottish Health Research Register) The Scottish Health Research Register SHARE adopts an approach which asks the public to consent to their data held in NHS databases to be used to determine their suitability for research projects. Additionally participants can consent for spare blood, left after routine venepuncture to be stored for future research studies. This has been implemented in tayside and Grampian with over 50,000 blood samples intercepted by March 2017. Anyone over the age of 11 years in Scotland can participate.
HALTHALT is a phase II/III, multicentre, randomised controlled trial in patients with advanced non-small cell lung cancer (NSCLC). Patients will have a defined, actionable mutation responding to targeted tyrosine kinase inhibitor (TKI) therapy and 3 or fewer sites of oligoprogressive disease, which will have developed after becoming resistant to targeted TKI treatment. 110 patients will be randomised to phase II of HALT with participants allocated to receive Stereotactic Body Radiotherapy (SBRT;73 p
HCV Research UKHCV Research UK is a UK-wide consortium established in 2011 to underpin research into hepatitis C (HCV). This was achieved by establishing a biorepository and clinical research database. The biorepository is housed in the MRC-University of Glasgow Centre for Virus Research, directed by Dr John McLauchlan and managed by Dr Sarah McDonald. Samples have been obtained from around 10,000 patients. Access to samples and data is governed by a Tissue and Data Access Committee (TDAC). These are revie
HPB BiobankProspectively collected fresh tissues from surgery. All patients fully consented. Snap frozen paired cancers and normal tissues. Stored in liquid nitrogen HCC Cholangiocarcinoma Liver mets Benign tumours Gallbladder cancer Pancreas and ampullary cancers 1010 samples currently in bank
Human Biomaterials Resource CentreThe HBRC is an HTA-licensed biorepository dedicated to the collection of appropriately consented high quality human biomaterials, their processing, storage and distribution to biomedical researchers. The HBRC resides within the purpose-built Advanced Therapies Facility (ATF) within the College of Medical and Dental Sciences (CMDS) at the University of Birmingham (UoB). The ATF also houses both cell and gene therapy manufacturing units. Samples are collected, processed and stored (or released) f
Human Developmental Biology Resource (HDBR)The Human Developmental Biology Resource (HDBR) is an ongoing collection of human embryonic and fetal material ranging from 3 to 20 weeks of development. Material is available to researchers internationally following registration with the tissue bank. Jointly funded by the MRC and Wellcome Trust, the biobank has been operating since 1999 and is based at two centres: Institute of Genetic Medicine ? Newcastle University and the Institute of Child Health ? University College London. Tissues can
HYWEL DDA BIOBANKThis is a newly opened University Health Board Biobank initially concentrating on lung and breast material but will expand to other specialities in the future..
ICHTBHuman tissue bank holding samples in a variety of different formats at Imperial College London
ICON9 TrialAn international phase III randomised study to evaluate the efficacy of maintenance cediranib and olaparib combination therapy or olaparib alone in patients with relapsed platinum-sensitive ovarian cancer following a response to platinum-based chemotherapy
IDRIS TrialPhase III randomised study of immunomodulatory therapy in high risk solitary bone plasmacytoma. IDRIS is a randomised, open label, multicentre phase III study. The aim is to investigate whether the administration of adjuvant lenalidomide and dexamethasone following standard radiotherapy treatment for SBP prevents or prolongs the time to development of further plasmacytomas or progression to myeloma, or death (whichever comes first), in patients with high-risk disease compared with RT only.
INCA TrialINCA is a multicentre, randomised, phase II trial comparing IO-R-CVP with Gem-R-CVP in the first line treatment of patients with DLBCL who are not fit for anthracycline-containing chemotherapy. 132 patients will be randomised to receive either IO-R-CVP or Gem-R-CVP. Samples collected for trial: 7ml EDTA blood sample taken at baseline; Formalin fixed paraffin embedded tumour block - both sent to HMDS, Leeds. Blood serum sample (4.9ml) taken at Baseline (between day -14 pre registration a
Infectious Diseases BioBank at King's College LondonFractionated blood products from patients with HIV, hepatitis C viral infections and others with bacteraemias.
interNational Anaplastic Thyroid Cancer Tissue Bank (iNATT)The primary objective is to establish an international anaplastic thyroid cancer tissue collection to facilitate research. Patients have the option to donate blood samples and clinical data. Research proposals will be accepted from academic and industry research parties from the UK and internationally. All research proposals will be submitted to the multidisciplinary iNATT Steering Committee for assessment. As the volume of tissue collected per patient is expected to be of small volume, by
IoN TrialIoN is a multicentre phase II/III asking is ablative radioiodine necessary for low risk differentiated thyroid cancer patients. 560 patients will be recruited and randomised 1:1 to receive radioiodine ablation or no ablation. Samples collected during trial: Stimulated Tg blood samples for patients taken at the treatment visit, 2 months post treatment, 6-9 months post treatment and every 6 months thereafter for 5 years.
kings college Haemato -Oncology Tissue bankThe objective of our Tissue Bank is to serve as an international bioresource to facilitate basic and translational research into the aetiology, diagnosis and prognosis of blood cancers and to pursue this aim in a manner that complies with all laws, regulations and industry standards that apply to research tissue banking.Thus, our bank is rich in material from adult patients with pre-leukaemic and bone marrow failure disorders, including myelodysplastic syndromes, aplastic anaemias and paroxysmal
King's Health Partners Cancer BiobankKing's Health Partners Cancer Biobank collects blood, tissue and urine samples from patients with a range of cancer types who are referred to Guy's & St Thomas' NHS Trust. The Breast Biobank alone has been providing tumour samples with matching clinico-pathological data for research studies since the 1970's. Other tumour types including lung, head and neck, prostate, UGI, bladder, colorectal, lymphoma and MPD have been added since 2008. The Biobank is accessible to both academic groups and comme
King's Paediatric Liver Tissue BiobankThe paediatric liver tissue bank contains samples from children with rare liver diseases taken longitudinally.
LBIH BiobankThe LBIH Biobank has been specifically created to provide SMEs and academic researchers with high quality biosamples, data, and analytical services. We house a vast array of biosamples, both cancerous and non-cancerous, and have the ability to collect bespoke samples and data to suit the needs of researchers. We have access to a wide variety of samples types including, but not limited to, frozen tissue, fresh tissue, blood products, urine and FFPE blocks. The LBIH Biobank can further process
Leeds Breast Research Tissue BankThe Leeds Breast Research Tissue Bank (LBRTB) was established in 2010 and collects malignant and normal breast tissue and associated samples from donors consented through the Leeds Teaching Hospitals Trust. The LBRTB is based in the Leeds Institute of Cancer and Pathology on the St. James's University Hospital site and is led by Professor Valerie Speirs. The LBRTB is a founder member of the Breast Cancer Now Tissue Bank (BCNTB), a ground-breaking multi-million pound initiative linking five centr
Leeds Dental Institute/School of Dentistry Leeds, Skeletal Tissues Bank Tissue bank which stores teeth.
Leeds Multidisciplinary Research Tissue BankBackground: The Leeds Biobanking and Sample Processing Facility (LBSPF) is based at St James?sUniversity Hospital and is an important element in the Leeds Clinical Research Facility (LCRF). LBSPF is dedicated to providing a sample processing service for clinical trials, and for many biobanking activities within the University and Leeds Teaching Hospitals Trust. These currently include collections of tissue, and fluid samples such as blood and urine obtained from consented patients diagnosed wi
Leeds NIHR Biomarker Research Tissue BankBackground: The Leeds NIHR Biomarker Research Tissue Bank (RTB) is part of a National Institute for Health Research (NIHR) Programme Grants for Applied Research award, focused on biomarker evaluation in selected disease areas. The RTB was established for the multicentre collection and storage of samples from patients with liver diseases recruited within a randomised controlled trial (ELUCIDATE) of a biomarker panel, renal cancer patients and patients undergoing kidney transplant. The Leeds
Leicester Cardiovascular BioresourceThe Leicester Cardiovascular Bioresource recruits both patient populations and healthy cohort through a number of recruitment protocols.
Leicester Institute for Lung Health Research Tissue BankMedical research is currently in an era in which thousands of genes, RNA molecules and proteins can be analysed in a single experiment, meaning that large numbers of potential molecular markers for disease are being identified. To validate and translate these biomarkers large series of tissue and other biosamples are required. The Leicester Institute for Lung Health (LILH) Research Tissue Bank (RTB) is intended to meet this need and to facilitate high quality research. The LILH RTB will support
Liverpool Musculoskeletal BiobankThe Biobank aims to facilitate musculoskeletal research. To support primarily research in the University of Liverpool. It will also support other research partners both nationally and internationally. A variety of musculoskeletal tissues are collected prospectively from consented patients undergoing both elective and trauma orthopaedic surgery. Patients demographic and medical history is obtained as well as outcome and quality of life assessment scores.
Manchester Allergy, Respiratory and Thoracic Surgery (ManARTS) BiobankCollection of samples from patients with respiratory and allergic diseases
Manchester Eye Tissue RepositoryRepository of post mortem donor eye tissue collected after removal of the corneas for transplantation. It has been established particularly for research into macular disease (age-related macular degeneration), but other ocular tissues have been stored frozen including peripheral retina, sclera, lens, vitreous and optic nerve. Macular tissue has been stored frozen for immunohistochemistry (by embedding in OCT) and for biochemical studies. The donor tissue had been genotyped in relation to AMD
MCRC BiobankFacilitating high quality cancer research by bringing a flexible and committed approach to ethical sample and data collection
MDSBioMolecular and functional characterisation of bone marrow function in normal subjects, myelodysplastic syndromes (MDS), acute myeloid leukaemia (AML) and secondary disorders of haematopoiesis
MesobanKA global solution to a global problem. Mesobank is a Research Tissue Bank dedicated to the study of mesothelioma. We provide a comprehensive sample and data set from patients with mesothelioma and support biomedical research directly concerned with asbestos related disease undertaken within the UK, EEA, USA, Canada, Australia and New Zealand.
Molecular Investigation of Haematopoietic Malignancy StudyThis study focuses on procuring diagnostic, relapse, remission and progression specimens from Haemato-Oncology patients. This allows researchers to be able to investigate the development and progression of these malignancies in addition to studies into the unique microenvironment. The tissue is stored and equipment maintained to strict guidelines to ensure quality of specimens; the vast majority as single cell suspensions. Also available are samples from the Haemato-Oncology tissue bank whic
MRC Brain Banks NetworkThe UK Brain Bank Network is an initiative, led by the MRC, to establish a coordinated national network of UK brain tissue resources (banks) for researchers to use. The banks store post-mortem brain and central nervous system (CNS) tissue donated by the public for diagnosis and research into disorders. Advances in understanding genetics and many of the molecules that define brain function mean that more and more research questions can be answered from human brain tissue.
Multiple Sclerosis and Parkinson's Tissue BankThe Multiple Sclerosis and Parkinson?s Tissue Bank is a national collection of CNS tissue samples donated by individuals with multiple sclerosis (MS), Parkinson?s disease and related neuroinflammatory and neurodegenerative conditions. The Tissue Bank?s mission is to facilitate discoveries by making well-characterised human material of the highest quality readily available to the research community engaged in studies aimed at finding the cause and better treatments for MS and Parkinson?s. Further
Myeloma XII clinical trial samplesSamples collected from myeloma patients at first relapse registered into the Myeloma XII trial, and sent to the following central labs: 1. Central immunology laboratory, University of Birmingham - peripheral clotted blood and urine collected at various timepoints throughout the trial; 2. Haematology Malignancy Diagnostic Service (HMDS) laboratory, St James's University Hospital, Leeds - bone marrow aspirate, collected at various timepoints throughout the trial; 3. Leeds Institute of Canc
National CJD Research & Surveillance Unit (NCJDRSU) BioResourceBioResource for human prion disorders including cerebrospinal fluid, blood, and urine.
National Diet and Nutrition Survey (NDNS)A National cross sectional population based survey. Additional data available including 4 day food diary, BP, biochemical analytes
National Unified Renal Translational Research Enterprise (NURTuRE)The NURTuRE project was devised to create a national kidney biobank as recommended in the UK Renal Research Strategy 2016. Strategic Aims: To work towards achieving this NURTuRE will: 1. Create a national Kidney Bio Bank for collection and storage of biological samples from 3,000 CKD patients and up > 800 NS patients, to provide a strategic resource for fundamental and translational research. 2. Develop and implement proactive UK protocol driven cohort studies in CKD and NS to investiga
Newcastle Biobank, Newcastle UniversityNewcastle Biobank is a research tissue bank within Newcastle University operating under Human Tissue Authority (HTA licence no. 12534). The biobank facilitates the collection of samples (excess to diagnostic requirement) from patients and volunteers for use in medical research. Applications are made to Newcastle Biobank to: (1) Establish a new sample collection for use in future unspecified research; (2) Access existing samples within the biobank. Newcastle Biobank also accepts legacy collect
Newcastle Bone and Joint BiobankWe support biological studies of the mechanisms of joint destruction in musculoskeletal diseases. There are more than 200 types of arthritis and rheumatic disease, and more than 7 million people in the UK have long-term health problems due to arthritis or a related condition. It is not only adults that are affected - one child in every 1000 has arthritis. A number of the current research projects in our unit are looking at joint destruction and implant development and rely on the collectio
Newcastle Institute of Transplantation BiobankBiobank dedicated to the collection and storage of both donor and recipient samples prior to, during and following solid organ transplantation.
Newcastle MRC Centre Biobank for Rare and Neuromuscular DiseasesThe Newcastle MRC (Medical Research Council) Centre Biobank for Rare and Neuromuscular Disease is located at the International Centre for Life (Institute of Genetic Medicine, Newcastle University). The MRC Centre for Neuromuscular Diseases is a partnership between Newcastle University and the UCL Institute of Child Health and Institute of Neurology, and is one of the MRC's translational research centres in the UK. The Newcastle MRC Centre Biobank and the affiliated biobank located at the Ins
NHS Cord Blood BankWe endeavor to minimise waste and process failure in the cord blood supply chain however, inevitably there is donated material that is surplus to clinical requirement or unsuitable for therapeutic use. We are in a unique position to supply this donated material for its own research and development, also to the NHS and to authorised external organisations for specific uses. Non Clinical Issue (NCI) operates on a cost recovery basis, We do not charge for material provided but recovers the costs of
NHS GG&C Gastroenterology Researchers Tissue BioresourceGastrointestinal tissue bank
NHS Grampian BiorepositoryThe Grampian Biorepository was develope to provide core facilities that could undertake research based around the collection, storage, analysis and distribution of human biological samples collected within NHS Grampian. The biorepository supports a range of tissue based projects. The main areas of research activity are translational research programs in colorectal cancer, lung cancer. In addition we have the following collections: orthopaediac tissues and liver samples, We have access to th
NICAM: Nilotinib treatment for c-KIT mutated advanced AMMPhase II single arm study evaluating the activity of nilotinib in rare c-KIT mutated acral and mucosal melanoma (AMM). Entry into the trial is a 2 step process. Patients presenting with AMM are first registered (Step 1) for screening including confirmation of c-KIT mutation status. Eligible patients who proceed to study entry (step 2) commence treatment with nilotinib 400 mgs twice daily for as long as they continue to benefit from treatment.
NIHR BioResourcePanel of over 100,000 highly characterised healthy volunteers and patients with common and rare diseases, who are willing to be approached to participate in research studies investigating the links between genes, the environment, health and disease. Volunteers who join the NIHR BioResource donate their DNA via a blood or saliva sample which is used together with other information (e.g. gender, ethnicity, health records), to match them to specific research studies. Genotyping information via hi
NIHR Exeter Clinical Research FacilityNIHR Exeter Clinical Research Facility is a partnership between the University of Exeter Medical School and the Royal Devon and Exeter Foundation Trust. It is dedicated to facilitation of clinical and translational research. We have two main collections: the Peninsula Research Bank (PRB) and the Royal Devon and Exeter Tissue Bank (RDETB). The PRB has ethics to accept gifted samples from completed studies, and the bulk of the collection is from a dedicated biobank collection called EXTEND (the
NIHR National Biosample Centre (UK Biocentre)The NIHR National Biosample Centre is a not-for profit enterprise supporting NIHR funded researchers across the UK. Control and rights to all samples managed by us remains with the Investigator. We offer at scale storage and processing of bio-samples with the capacity for up to 20 million stored samples in automated storage systems. Additional capacity exists for managed freezer collections and vapour phase liquid nitrogen cryostorage. We provide automated DNA/RNA extraction/normalisation and
NIHR Nottingham Digestive Diseases CollectionThe NIHR Nottingham Digestive Diseases Biomedical Research Unit (NDDBRU) has become the central hub to the gastroenterology and hepatology research within the partnership of University of Nottingham and Nottingham University Trust, bringing together 67 principal investigators bridging basic scientific and clinical fields. Among this large group, we have expertise in a wide range of areas, techniques and methodologies although we focus on early translational studies including pre-clinical and pha
NIMRAD-TRANSA retrospective sample collection of formalin fixed paraffin embedded (FFPE) pre-treatment diagnostic biopsies from patients with Head and Neck Squamous Cell carcinoma (HNSCC) enrolled on the NIMRAD trial.
Northern Ireland Biobank (NIB)Northern Ireland Biobank was established in 2010 to collect, store and distribute human samples for translational research and is primarily funded by the Northern Ireland Health and Social Care Research & Development Division of the Public Health Agency. Cancer Research UK (CR-UK), the Friends of the Cancer Centre and Prostate Cancer UK have also provided financial support. The NIB complies with approvals from both the Office of Research Ethics in Northern Ireland and HSC R&D governance to host
Norwich Research Park BioRepository? To provide a quality histopathology service to researchers, working with the Trust Cellular Pathology department. ? To offer scientific expertise in sample collection and preparation, and guidance on all aspects of tissue based research, on a consultancy basis to researchers. ? To act as a network hub for researchers using human tissue, to enable new relationships, reduce unnecessary duplication of work and optimise use of samples.
Nottingham Health Science BiobankThe Nottingham Health Science Biobank (NHSB) and related bioinformatics strategy is led by Dr Brian Thomson, Director the NHSB and Clinical lead for the 100K Genome project. This is a Trust led Biobank which is working closely with the Biomedical Research Units (BRUs), University of Nottingham and Nottingham NHS Treatment Centre on behalf of the wider scientific community. The aim is to provide a single, centralised, quality assured, biofluid and tissue resource to underpin translational studie
NRS Lothian BioresourceThe NRS Lothian Bioresource provides access to a wide range of characterised tissue collected in a healthcare setting for use in research. This includes surplus material from diagnostic specimens and surgical procedures. The Bioresource Lothian can facilitate collection of the following material: Pathology archive samples Surplus diagnostic samples - such as blood, urine or other bodily fluids Surplus diagnostic or surgical tissue Bespoke collections of tissue
NRS TC GlasgowThe NHS Greater Glasgow & Clyde Bio-repository is part of NHS Scotland NHS Research Scotland Infrastructure. There is a network of Bio-repository across Scotland designed to encourage use of tissue in research and boost availability of tissue across Scotland. Each Bio-repository node holds the responsibility for tissue governance for local and partner Health Boards with a main focus on facilitating access to surplus diagnostic and surgical tissue for use in research.
Obesity Research Biobank Syndicate (ORBiS)Bariatric surgery produces substantial, long-term weight loss with reduced morbidity and mortality. Genetics can strongly influence this response, as well as the initial propensity to obesity. Several genes have been implicated but more in-depth mechanistic studies are needed to understand how genes affect energy regulation and mediate the beneficial effects of bariatric surgery. The Obesity Research Biobank Syndicate (ORBiS) aims to fulfil this need. It provides a comprehensive collection of
Oncology Clinical Trials Office, University of OxfordOCTO was established in 2002 to run trials concerned with the practical application of high quality research into innovative and effective cancer therapies and prevention strategies. Our portfolio of trials includes a range of projects from first in human drug trials through to large Phase III clinical studies. Studies assess interventions including radiotherapy, drug combinations and novel imaging techniques. Tumour types include: colorectal, oesophageal, melanoma, lung, breast, cervical,
Orchid Tissue BankThe Orchid Research Tissue Bank is a Genito-Urinary tissue bank collecting and storing samples of prostate, testis, penile, kidney and bladder cancer. It consists of fresh frozen and formalin fixed tissue samples as well as whole blood, plasma and serum collected from patients with Genito-Urinary cancers or being investigated for malignancy. The bank was set up with the purpose of expanding the collection of male-specific cancers; providing material for scientific research aiming to discover n
Oxford Cell & Tissue BiobankBiobank is located within the Oxford University Hospital NHS Foundation Trust HTA Human Application license no 11106. Retrieves tissue for transplantation and research from living and from deceased persons. Tissue retrieved for Research so far includes: Brain, Spinal Cord, Heart Valve, Eyes, Testicular, Ovarian. This Oxford Biobank service is expanding and will consider requests for retrieval of other cells and tissues
Oxford Musculoskeletal BiobankThe Oxford Musculoskeletal Biobank (OMB) is a resource of tissue and blood samples donated by patients for use in medical research (primarily musculoskeletal). The Biobank provides a simple and efficient way to collect and store samples according to regulatory requirements, and it ensures fair access to the samples. Samples will usually be used for research studies which may contribute to increasing the knowledge and understanding of musculoskeletal diseases in order to improve diagnosis and tre
Oxford Radcliffe BiobankThe Oxford Radcliffe Biobank (ORB) holds a Human Tissue Authority (HTA) licence for storage of human material for research, licence number 12217. The Licence Holder is the University of Oxford and the Designated Individual (DI) is Dr Clare Verrill. The licence covers activities within Oxford, at the main site, the John Radcliffe Hospital, and at the satellite sites, Cowley Store, Churchill Hospital, Nuffield Orthopaedic Centre and Department of Pharmacology. ORB provides infrastructure to un
Oxford Transplant BiobankThis collection is currently in development, below are the proposed plans: This is a local biobank, funded by the Oxford Biomedical Research Centre (BRC) Transplantation Working Group, targeting living organ donors, their recipients and recipients of deceased organ donors looked after in the Oxford Transplant Centre. Sample collection consisting of: -Blood and urine samples taken from the living donors at two time points during the donor management period -Blood and urine samples taken fr
Pancreatic Cancer Research Fund Tissue BankThe Pancreatic Cancer Research Fund Tissue Bank is the world's first national pancreas tissue bank and will accelerate research into pancreatic cancer. The Tissue Bank is funded by the medical research charity Pancreatic Cancer Research Fund, and is a unique collaboration between the charity, Barts Cancer Institute, Queen Mary University of London and six key NHS partners throughout the UK, each renowned for its expertise in treating pancreatic cancer
Partner TrialRandomised, phase II/III, 3-stage trial to evaluate the safety and efficacy of the addition of olaparib to platinum-based neoadjuvant chemotherapy in breast cancer patients with triple negative and/or gBRCA sub-type.
Penile TPFA Phase II non-randomised multicentre trial of docetaxel, cisplatin & 5-fluorouracil chemotherapy (TPF) in locally advanced and metastatic carcinoma of the penis. 26 evaluable patients recruited to receive Docetaxel 75mg/m2 day 1, cisplatin 60mg/m2 day 1, 5-fluorouracil 750mg/m2/day (day 1-5), peated at intervals of 21 days. The primary endpoint, measured by RECIST v1, (complete remission rate + partial remission rate). Secondary endpoints are te proportion of patients with inoperable locoregion
PHE MOHS Ebola Biobank During the Ebola outbreak in Sierra Leone in 2014-15, residual clinical specimens and accompanying data were collected from routine diagnostic testing in Public Health England (PHE) led laboratories. Approximately 10,000 samples of which 1,440 are positive for Ebola along with all the accompanying data have been transferred to PHE laboratories in the UK for curation by PHE. The Ministry of Health and Sanitation in Sierra Leone (MOHS) have retained ownership of the data and materials, and hav
PHOENIX DDR-Anti-PD-L1 TrialPHOENIX DDR/Anti-PD-L1 Trial: A pre-surgical window of opportunity and post-surgical adjuvant biomarker study of DNA damage response inhibition and/or anti-PD-L1 immunotherapy in patients with neoadjuvant chemotherapy resistant residual triple negative breast cancer
PHOTO Translational bladder cancer biorepositoryTranslational study associated with the PHOTO trial - A pragmatic randomised controlled phase III trial, investigating the efficacy transurethral resection of bladder tumour (TURBT) using photo-dynamic diagnosis (PDD) under blue light in intermediate and high risk non-muscle invasive bladder cancer (NMIBC). The translational study is establishing a well-characterised cohort of patients with intermediate and high-risk NMIBC including clinical data, urine, blood and tumour specimens that woul
plasmaMATCHThe UK plasma based Molecular profiling of Advanced breast cancer to inform Therapeutic Choices (plasmaMATCH) Trial: A multiple parallel cohort, open-label, multi-centre phase IIa clinical trial aiming to provide proof of principle efficacy for designated targeted therapies in patients with advanced breast cancer where the targetable mutation is identified through ctDNA screening
POETIC: Trial of perioperative endocrine therapy ? individualising carePrimary aim: To determine whether two weeks perioperative aromatase inhibitor (AI) therapy before and after surgery improves outcome compared with standard adjuvant therapy. Eligibility: Postmenopausal women with ER/PgR positive invasive breast cancer. Trial design: Phase III, multicentre, randomised trial Target accrual: 4350 patients Patients will be allocated in a 2:1 ratio to PERIOPERATIVE THERAPY with an AI for 4 weeks (two weeks before and two weeks after surgery) or NO PERIOPERATIVE T
PORT TrialSkin biopsies will be obtained from patients for translational studies to identify biomarkers of immunological response to the combination of pembrolizumab and radiotherapy in patients with advanced Cutaneous T Cell Lymphoma (CTCL).
POUT-TPOUT-T: The translational substudy of a phase III randomised trial of peri-operative chemotherapy versus surveillance in upper tract urothelial cancer. The objectives of POUT-T are: to investigate the molecular pathogenesis of Upper Tract Urothelial Carcinoma (UTUC); to identify prognostic and predictive biomarkers of UTUC; and to identify diagnostic biomarkers of UTUC. POUT-T participants are requested to provide the following specimens pre-operatively, post operatively, 6 months followin
PRIMETIMEPost-operative avoidance of radiotherapy: biomarker selection of women categorised to be in a very low risk group by IHC4+C
PTCL Biobank An Observational Study of Peripheral T cell Lymphoma: Establishment of a Biobank and Database. The outcome of this study will be a biobank of PTCL cases with linked clinical data and serum, saliva and plasma samples to enable assessments of treatment response and prediction of relapse.
Public Health England Seroepidemiology UnitThe basis of the PHE (formerly the Health Protection Agency) Seroepidemiology Programme is a large collection of sera representative of the general population of England, forming a unique and valuable public health resource. The collection is stored and maintained by the Seroepidemiology Unit (SEU) at the Public Health Laboratory (PHL), Manchester. Sera submitted to the SEU are residues of specimens submitted for diagnostic testing. They sample the population range and are anonymised prior to
Pulmonary Hypertension Biobank at Imperial CollegeThe Biobank comprises a collection of samples (plasma, serum, blood samples for DNA and RNA extraction, and urine) from patients who have been referred to the National Pulmonary Hypertension Service at Hammersmith Hospital, London.
QTL Programme at MRC HGUThe QTL (Quantitative Trait Locus) programme leverages the special population structures in our Scottish and Croatian cohorts to deliver biological understanding of the causes of variation in complex traits. A substantial part of the genetic component of disease remains hidden in rare variants that cannot be easily detected in traditional genome-wide association studies (GWAS), which have identified many common variants contributing to complex disease. Otherwise rare variants can increase in fre
QUOD - Quality in Organ DonationOrgan donation and transplant saves thousands of lives a year and could be considered one of the greatest successes in modern medicine. However, over the past decade, there has been an ever increasing need for organs throughout the UK, far surpassing the supply. This is a pattern that is predicted to worsen over the next 10 years. As many as one in three patients on the transplant waiting list will die or become too unwell to receive a transplant as a result of this disparity. To address
R2W TrialR2W is a randomised, noncomparative phase II trial of subcutaneous bortezomib, cyclophosphamide, rituximab (BCR experimental arm) versus fludarabine, cyclophosphamide, rituximab (FCR control arm) for initial therapy of waldenstrom's macroglobulinemia. The overall aim of the study is to examine the safety and efficacy of the proposed BCR regimen and to determine whether it warrants further investigation in a randomised phase III setting. 56 patients will be recruited and randomised 2:1 in favo
RAPPERRAPPER (Radiogenomics: Assessment of Polymorphisms for Predicting the Effects of Radiotherapy) is a national radiogenomics study investigating the association between common genetic variation determined by single nucleotide polymorphisms (SNPs) and radiation toxicity.
RATHL TrialRATHL is a multicentre, randomised, phase III trial comparing treatment outcome for patients with advanced Hodgkin lymphoma, using FDG-PET imaging after 2 cycles of ABVD to determine response and subsequent management. Recruitment target: 1200 patients Patients received 2 cycles of ABVD and then had a PET-CT scan. PET negative patients were randomised to either ABVD or AVD for a further 4 cycles. PET positive patients received either BEACOPP-14, for 4-6 cycles or BEACOPP escalated, for
RE-AKTA multicentre prospective, randomised, phase II interventional study in mCRPC patients previously treated with 1-2 lines of chemotherapy and at least 12 weeks of abiraterone with a safety run-in and single stage phase II expansion cohort
Registry of Autoimmune Rheumatic DiseasesThe registry of autoimmune rheumatic diseases involves the standardised collection of blood and clinical information from individuals with several diseases such as lupus, rheumatoid arthritis, scleroderma, vasculitis, Sjogren's syndrome, polymyositis, and dermatomyositis, as well as patients with antiphospholipid syndrome. The great advantage of the registry is that it can provide researchers with complete sets of clinical blood samples to answer important clinical questions, helping to facilita
REPROCELL Europe LtdREPROCELL Europe Ltd is a Contract Research Organisation specialising in the use of fresh human tissues to better predict drug efficacy and safety during non-clinical drug development. We source a range of fresh healthy and diseased tissues from multiple providers, across the UK, Europe and the USA, for specific academic and pharmaceutical industry sponsored projects conducted within REPROCELL facilities. Services utilising fresh tissue include pharmacological assays, 3-D culture and induced pl
REQUITEValidating Predictive Models and Biomarkers of Radiotherapy Toxicity to Reduce Side-Effects and Improve Quality of Life in Cancer Survivors. The purpose of this international study is to try to predict which patients are more likely to have side effects from radiotherapy. Funded by the European Commission FP7 HEALTH scheme.
Respiratory Tissue ArchiveThis is a collection of bronchial and nasal biopsies collected between 1989 and February 2006 from volunteers with asthma, COPD and rhinitis, and age matched controls as part of the University of Southampton's ongoing respiratory research programme.
RIOWindow study of the PARP inhibitor rucaparib in patients with primary triple negative or BRCA1/2 related breast cancer (RIO)
RJAH Biobank for Studying Health and DiseaseOrthopaedic tissues Wax embedded and fresh frozen tissues of primary and secondary bone tumour and metastatic disease. If a certain tissue types are required with the correct Ethics and consent in place these could be collected and stored at the tissue bank.
SCOT translational sample collectionThe SCOT study enrolled more than 6000 patients over a 5 year period and is the largest single trial ever conducted in CRC. Tissues collected from patients entered in to the study are physically hosted in two sites; blood samples and blood fractions e.g. DNA, are held at the University of Oxford and FFPE samples are housed at the Glasgow Biobank. There are approximately 3000 blood and 3000 tissue samples in the collection. The associated clinical data is held by the Cancer Research UK Clinic
Scottish Human Papillomavirus Archive The Scottish HPV Archive is a biorepository of samples that provides a vital resource for researchers to improve the way we detect and manage HPV associated disease. The archive is housed within the Queen's Medical Research Institute, University of Edinburgh, and follows the governance policies of NHS Lothian for tissue collections and the bio-repository principles of the Lothian NRS Bioresource (SAHSC). It currently holds over 40,000 samples, the majority of which are cervical liquid-base
Sheffield Collaborating Centre of the Breast Cancer Now Tissue BankThe University of Sheffield collects malignant and normal breast tissue and blood samples from patients attending the Royal Hallamshire Hospital and Weston Park Hospital, Sheffield as part of a research project led by Prof. Angela Cox; "The role of angiogenesis and genome stability in breast cancer, and biosample collection". The research group specialises in the collection of longitudinal blood samples, including blood plasma for circulating DNA applications. Patients are invited to donate thei
St Thomas' Hospitals Plasma, serum & DNA Bio bank from patients with antiphospholipid antibodiesA frozen biobank collection of plasma, serum, and DNA from APS patients. Each sample is anonymised blood sample collected from patients who consent for its use in future research into Antiphospholipid Syndrome. APS is defined as the association of antiphospholipid antbodies (aPL) with arterial or venous thrombosis and /or pregnancy morbity. Antiphospholipid syndrome is an autoimmune disorder in which aPL are involved in the development of venous and/or arterial thrombosis.
STAMPEDE tbc
SUN StudyThe SUN study is a Bio repository of 6 monthly sequential blood samples from 350 men with Prostate Cancer - pre-treatment and through follow-up
SWIFT-RTBFetal tissue
TACT2: Trial of Acc. Adjuvant CT (Capecitabine)in EBCA randomised, phase III clinical trial with a 2 x 2 factorial design addressing two hypotheses: 1. That accelerating Epirubicin will improve the efficacy of the sequential schedules (based originally on the NEAT epirubicin/CMF schedule). 2. That the substitution of CMF by Capecitabine will not be detrimental to patient outcome but will offer advantages in Quality of Life and/or toxicity.
Taxotere as Adjuvant ChemotherapyA phase III multi-centre open-label randomised controlled clinical trial of standard anthracycline-based chemotherapy (fluorouracil, epirubicin and cyclophosphamide (FEC) or epirubicin and CMF (Epi-CMF)) versus FEC followed by sequential docetaxel in women with early breast cancer. 4162 patients were recruited between February 2001 and June 2003 from 103 UK centres and 1 Belgian centre. Tumour tissue was collected prospectively for subsequent biological studies, and blood samples for DNA extra
Tayside BiorepositoryTayside Biorepository is an established bio-resource responsible for the provision of a wide range of human tissue from consenting patients in addition to providing a large range services including staining and extraction methods.
The Airwave Health Monitoring Tissue BankThe Airwave Health Monitoring Study was established to evaluate possible health risks associated with the use of TETRA, a digital communication system used by the police forces and other emergency services. It is a long-term observational study following up the health of police officers and staff across Great Britain, with the ability to monitor both cancer and non-cancer health outcomes. Around 53,000 participants have been recruited between June 2004 and March 2015 with a response rate averagi
The Cleft CollectiveThe Cleft Collective is a longitudinal cohort study looking to investigate the biological and environmental causes of cleft and the best treatments of cleft on those affected and their families. The study comprises two separate cohorts, a Birth Cohort and a 5-year-old Cohort. The birth cohort is further split into two sub-groups, postnatal and antenatal, allocation to these groups is determined by the time of recruitment. Recruitment to the two cohorts is currently ongoing across the UK. A l
The PEACE StudyThe PEACE (Posthumous Evaluation of Advanced Cancer Environment) Study
The Swansea Neurology BiobankThe Swansea Neurology Biobank, (SNB) is a collaboration between Swansea University and Local Health Boards, collecting biological specimens from a range of neurological phenotypes.
Tissue Access for Patient Benefit (TAPb)We aim to facilitate the pathway for access, storage, use and transfer of human organs, cells and tissue between clinical centres within UCL Partners, academic groups in UCL, other universities, hospitals, medical researcher and biotechnology companies, to enhance the ability for researchers to access the materials they need. Alongside this, researcher will be able to exchange information and access guides on regulatory, ethics and practical issues concerning access, transfer and use of this typ
Tissue Solutions LtdTissue Solutions specializes in sourcing biological material for academics, pharma & biotech companies and CROs and is working with clients worldwide (USA, UK, Europe and Japan). We are a virtual tissue bank, working with multiple sources to acquire samples on behalf of our clients for use mainly during the preclinical research phase. We never retain tissues ourselves for our own use. We provide access to banked human tissues and set up prospective collections in the UK and USA. We specialise i
TNT: Triple Negative breast cancer TrialTNT is a phase III, multi centre, randomised trial of carboplatin versus docetaxel in women with ER-, PgR- and HER2- metastatic or recurrent locally advanced breast cancer. Patients will be randomised (1:1) to carboplatin or docetaxel and will cross over to the alternative treatment (docetaxel (if randomised to carboplatin) or carboplatin (if randomised to docetaxel)) on progression. Trial Treatment: Group A: Carboplatin AUC 6, q 3 weeks for 6 cycles (18 wks) Group B: Docetaxel 100mg/m2, q 3
TOPARP: Ph. II Trial of Olaparib in Patients with advanced CRPCTOPARP is an open-label, single arm, two part adaptive design phase II trial of olaparib in mCRPC. Patients will receive single agent olaparib at a dose of 400 mg twice daily, continuously on a 28-day cycle, until objective disease progression or unacceptable toxicity or patient withdrawal for whatever reason.
TRACERx Tissue and blood from lung cancer patients
TRICON8BTRICON8B is the translational research sub-study of the ICON8B trial. The aim is to establish a large, comprehensive biobank comprising tumour tissue, blood and serial plasma samples with associated clinical data which will be an invaluable resource for high-quality translational research in ovarian cancer. ICON8B is a phase III randomised trial investigating the combination of dose-fractionated chemotherapy and bevacizumab compared to either strategy alone for the first-line treatment of wo
TwinsUKTwinsUK is the largest UK adult twin registry of twins used to study the genetic and environmental aetiology of age related complex traits and diseases.
UCL / UCLH Biobank for Studying Health and DiseaseThe Biobank stores normal and pathological specimens, surplus to diagnostic requirements, from relevant tissues and bodily fluids. Stored tissues include; snap-frozen or cryopreserved tissue, formalin-fixed tissue, paraffin-embedded tissues, and slides prepared for histological examination. Tissues include resection specimens obtained surgically or by needle core biopsy. Bodily fluids include; whole blood, serum, plasma, urine, cerebrospinal fluid, milk, saliva and buccal smears and cytological
UCL Eastman BiobankThe UCL Eastman Biobank will act as a physical repository for collections of biological samples and data for research purposes from consented patients at the Eastman Dental Institute and Hospital, University College London and University College London Hospitals Foundation Trust (Eastman). This will incorporate prospective collections of stored samples and new collections. It provides a unique opportunity to advance dental and medical research by making access to tissue surplus to requirements e
UCL GCRC Biobank During the course of two large ovarian cancer screening trials, United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) and United Kingdom Familial Ovarian Cancer Screening Study (UKFOCSS) two biobanks were established containing samples, images and data. These collections form the UCL-GCRC Biobank. Also included is a case control collection (UK Ovarian Cancer Population Study (UKOPS)investigating the role of genetics in ovarian cancer
UCL Infection DNA BankThe UCL Infection DNA Bank aims to facilitate research into infectious diseases through the enhanced availability of samples to researchers. This availability currently supports research in the UCL Division of Infection and Immunity but it will also support researchers nationally and internationally, increasing the potential for collaboration.
UCL Royal Free Hospital BiobankThe physical repository was established in Nov 2009 and is located within the Royal Free London NHS Trust, London UK. The UCL-RFH Biobank provides a biorepository facility to user groups on a cost-recovery model. Types of biospecimens include Serum, Plasma, Cells, Tissue, DNA, Urine etc. In particular, samples considered 'relevant material', such as tissues and cells, which are licensed by the Human Tissue Authority (HTA), can be stored long term. Existing holdings where appropriate can be tran
UK BiobankUK Biobank is a major national health resource, and a registered charity in its own right, with the aim of improving the prevention, diagnosis and treatment of a wide range of serious and life-threatening illnesses ? including cancer, heart diseases, stroke, diabetes, arthritis, osteoporosis, eye disorders, depression and forms of dementia. UK Biobank recruited 500,000 people aged between 40-69 years in 2006-2010 from across the country to take part in this project. They have undergone measures,
UK CLL Trials Biobank A collection of Chronic Lymphocytic Leukaemia samples from patients on clinical trials. Includes the trials; AdMIRE, ARCTIC, CHOP-OR, CLL210, CLEAR, COSMIC, RIAltO, FLAIR
UK ME/CFS BiobankParticipants: Over 500 participants included in the study including ME/CFS participants diagnosed by a physician and compliant with CDC ?94 (Fukuda) and Canadian Consensus Criteria (CCC); case definition compliance available for four other commonly-used criteria. ? Mild and Moderate ME/CFS ? Severe (Home-Bound) ME/CFS ? Multiple Sclerosis ? Healthy Controls Samples Available: Over 28,000 aliquots available. ? Whole Blood ? Serum ? Plasma ? RBCs ? PBMCs ? Blood for RNA Extract
UK MND CollectionsThe UK MND Collections include a DNA and Cell Bank and an Epidemiology Dataset. They were established to provide the international research community with a resource to identify and understand causative and disease modifying factors in motor neurone diseases. Initially conceived as a DNA bank from people with MND, spouse controls and family members, with EBV-transformed lymphoblastoid cell lines as an everlasting supply of DNA, the Collections have now evolved. The lymphoblastoid cell lines are
UK primary Sjogren's syndrome RegistryPeripheral blood samples (DNA, RNA, serum, PBMC) from patients with primary Sjogren's syndrome, with detailed contemporaneous clinical data at the time of sample collection.
UK real-world lymphoid tissue bankThe UK real-world lymphoid malignancies tissue Bank (UKTB) provides a national and international resource for research on lymphomas and other lymphoproliferative disorders including chronic lymphocytic leukamia. This Research Tissue Bank was set up in 2014 and given favourable ethical opinion (REC ref: 14/SC/0162). The samples are stored in the HTA licenced Faculty of Medicine Tissue Bank. The RTB currently holds matched normal and malignant frozen material from ~900 patients. The samples collec
UKALL14 TrialA randomized trial for adults with newly diagnosed acute lymphoblastic leukaemia. Multisite, randomised controlled trial, recruiting 811 patients over 7.5 years. Samples will be collected throughout the trial and sent to the central lab (Adult ALL MRD Lab @ UCL CI) as follows; - bone marrow samples taken at diagnosis, at recover post phase 1 and phase 2, post transplant (for those patients who proceed with a non-myeloblative transplant) and at relapse. - pheripheral blood sample taken durin
Ukall60 TrialThe UKALL60+ trial is a multi-centre, prospective, non-randomised, multiple pathway trial to document the safety, tolerability and efficacy of standard ?backbone? chemotherapeutic regimens in older patients with de novo ALL. Samples will be collected throughout the trial and sent to the central lab (Adult MRD lab at UCL CI) as follow: 1. At diagnosis (pre trial registration) 2. After Phase 1 Induction 3. After Phase 2 Induction 4. a) After Intensification (for patients on the pathway B ONL
UNIRAD UK Sample collectionRandomised, double-blind, multicentre phase III trial evaluating the safety and benefit of adding everolimus to adjuvant hormone therapy in women with high risk of relapse, ER+ and HER2- primary breast cancer who remain free of disease (UNIRAD).
University of LeedsSamples collected from patients in the CALIBER trial of chemoablation versus surgical management in low risk non-muscle invasive bladder cancer
University of Leicester Cancer Research BiobankThe Biobank collects and stores samples for local studies. Samples collected include; ?Frozen disease-affected tissue ?Paraffin embedded disease-affected tissue ?Blood ?Urine ?sorted stem cells
University of Liverpool - GCP Laboratory Facility Combined repository of clinical trial samples for ?future use?. Will include samples from clinical trials co-ordinated by the Liverpool Cancer Trials Unit and from studies with Liverpool Principal Investigators.
University of Southampton Faculty of Medicine Tissue BankThe Tissue Bank is licensed by the Human Tissue Authority (HTA) to source, organise, collect, prepare, store and distribute a diverse collection of human tissues and biological products. All tissue is collected with patient consent and distributed anonymously only to National Research Ethics Service (NRES) approved studies. This valuable resource is available to aid the study of cancer biology and other associated research. The Tissue Bank allows for rapid access to a plethora of biological
Veterinary BiobankThe School of Veterinary Medicine and Science of the University of Nottingham is establishing a biobank to collect and store biological samples for researchers to study human and animal diseases. The Biobank aims to develop a national veterinary health resource for vets and researchers, aimed at improving the understanding and treatment of a wide range of diseases.
VinCaPVinCaP is a phase II, multicentre, non-randomised trial of Vinflunine chemotherapy in locally-advanced and metastatic carcinoma of the Penis. 22 evaluable participants will be recruited from 9 centres and all patients will receive 4 cycles of IV vinflunine 320mg/m2 on day 1, to be repeated at intervals of 21 days. The primary endpoint, determined by RECIST v1.1, is clinical benefit (objective response + stable disease rate) measured after four cycles of vinflunine chemotherapy. Secondary endpoin
VORTEX-BIOBANKCollection of matched tumour and normal tissue samples, FFPE blocks and EDTA blood samples from human soft tissue sarcoma (STS).
Wales Cancer BankThe Wales Cancer Bank (WCB) was set up in 2004 and consented the first patient in 2005. The project is hosted by Cardiff University and receives funding from the Welsh Government, Cancer Research Wales and Velindre Charitable funds. A Cancer Bank is literally a collection of tissue and blood which has been collected from patients where cancer is a possible diagnosis and is being stored to facilitate future research into cancer. Statistics suggest that four out of ten people will be diagnos
Walton CSF Research BiobankThe Walton CSF Research Biobank (WCRB) was established to promote multidisciplinary basic and translational neurology research. WCRB collects and stores CSF samples matched with bloods i.e. serum, plasma and cell fraction with relevant clinical details. As many neurology conditions are of low incidence, an establishment of a research sample bank based on CSF and blood samples within neurosciences archives will facilitate multicentre research. CSF is a precious fluid and much of the research th
Walton Research Tissue BankThe Walton Research Tissue Bank (WRTB) was established in 2011 to facilitate and promote multidisciplinary basic and translational neuro-oncology research. All patients undergoing surgery are invited to participate in the tumour research programme. With appropriate research consent, tumour and matched blood samples are obtained and stored in the tissue bank. These samples are used to investigate the relationship between tumour biology, response to treatment and outcome in different tumour type
Watch and Wait TrialWatch and Wait is a randomised phase III trial to determine whether initial treatment with rituximab in patients with advanced stage asymptomatic follicular lymphoma (grades 1, 2 and 3a) results in a significant delay in the initiation of chemotherapy or radiotherapy and the impact of each strategy on patient-related quality of life. 360 patients randomised to receive either Rituximab treatment and maintenance or to a Watch and Wait strategy. Samples collected for trial: Formalin fixed pa
York Tissue BankIn collaboration with York Teaching Hospital NHS Trust, the University of York has established the York Tissue Bank: a tissue bank to help research into human disease. We aim to collect, store and build a repository of human tissue samples, such as urine, blood and tumours. These can then be given to researchers for their studies. These studies will aim to improve our understanding of human health and potentially lead to new methods of diagnosis, better treatments and vaccines for a wide range o